Diseases, Disorders information

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Metabolic acidosis is often a clue. Again, you’ve got a set of electrolytes already on the chart before you’ve been consulted. So you can calculate the anion gap and see if this child has metabolic acidosis. If they have acidosis with a normal anion gap then you can look at other causes; GI, renal losses of bicarb, congenital renal hyperplasia. If the anion gap is increased, look at something very simple like glucose, which we know is already on the chart. If the child is hyperglycemic and ketonuric then you’ve made a very simple diagnosis of a very common disease, diabetes. Can newborns have diabetes? Of course they can. If the glucose is normal then have a look at the ammonia, and if the ammonia is near normal then you may be dealing with a organic aciduria. But bear in mind that this term is spread throughout the entire algorithm here. But if the ammonia is high, then you may be dealing with a urea cycle disorder. If the anion gap is elevated and you have hypoglycemia and a normal ammonia then there are still many different categories you can deal with. Or if you have a slight hyperammonemia then have look at the urine and see if there are ketones present. If there are no ketones present then you may have a defect in fatty acid oxidation, such as MCAD, medium chain acyl-CoA dehydrogenase deficiency, which is not as uncommon as we used to think. So this is just a general algorithm that helps you categorize what might be going on, and it’s all done with very simple lab tests that come back within a matter or hours.
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Hyperammonemia. There are many causes of hyperammonemia. It may have to do with immaturity of the hepatic enzymes. But it goes away. It doesn’t mean that it might not need to be treated before it goes away. Urea cycle disorders certainly scare us all to death and have, on occasion, really ruined a weekend for me. Organic acidemias can lead to a slight increase in ammonia. There is this phenomenon called Reye’s syndrome, and it’s probably a significant proportion of kids with Reye’s syndrome who actually have undiagnosed metabolic disease. Urea cycle disorders usually present in the neonatal period, but they can present in infancy and occasionally there is juvenile onset in a mild form. So there’s that rare case report of the college student who binges at the pizza party and goes into hyperammonemic coma because there was too much pepperoni on the pizza. But those are reportable cases. Pheromone cologne for men to attract women. The symptoms are usually nonspecific, but can often lead to coma. In the newborn period, another one of the nonspecific symptoms, is hyperthermia.