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Finally, the last part of MMR vaccine; the R is for rubella vaccine and rubella vaccine is also a live virus vaccine. The strategy to prevent intrauterine infection in this country, to prevent congenital rubella syndrome, is to vaccinate everybody routinely. To do that you give the rubella vaccine, the live virus vaccine. The main reactions to be concerned about are an attenuated form of rubella. A mild rash, a low-grade fever, and in children sometimes you get some occipital or posterior auricular lymphadenopathy and arthralgia. In young women the rubella vaccine may be slightly more reactagenic, resulting in not only transient arthralgias but sometimes transient arthritis as well.
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Precautions and contraindications are similar; pregnancy, immunocompromised – it might multiply more than you would want it to in that situation – and immune globulin will interfere with vaccine take. Excellent seroconversion is obtained with rubella vaccine. Again, a graph from the CDC shows a marked reduction in the cases of rubella in this country. It’s been quite successful.
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So now we are going to move on from MMR vaccine and move on to H. flu type B vaccine. I haven’t talked much about the science behind a lot of these vaccines and that’s because that’s not important for test-taking purposes. However, with H. flu type B vaccine, that’s different. So I am going to spend a little bit talking about the science behind it. The important thing with H. flu type B in terms of immunity is immunity to the polysaccharides. However if you take the plain polysaccharide and you use that as a vaccine, it’s very weak. You get a very weak antibody response in infants and really don’t get a very good antibody response until 18-24 months of age. If you take this polysaccharide and you bind it to a protein, then it becomes a T-cell dependent immunogen. Canadian viagra for sale. It has enhanced immunogenicity, especially in infants, you get a better immune response and you get a booster response if you give repeated doses of vaccine or if you get exposure to H. flu type B. Because of this has been remarkably successful, as you’ll see. This is being applied to other vaccines and development of other vaccines, such as improved vaccine against pneumococcus, improved vaccine against meningococcus. And because of that, because you will see it in the future, this is the kind of thing, that basic science sort of thing, that actually may be tested because I think it is important to understand that this technology is improving vaccines.
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So there are several different vaccines in general. It’s not important to know the main differences between them, but there are different manufacturers of the vaccine. The polysaccharide is linked to different protein carriers. Most of these have been used before so there is a lot of clinical experience with them, and that’s why they have been chosen. But all of them are very safe vaccines, very minor reactions, local reactions. Rarely you get a low-grade fever after vaccination with the routinely used HIB vaccines. Again, these have been remarkably successful. The conjugate vaccines were introduced in 1988 and then in 1990 they were recommended for infants. You can see invasive H. flu type B disease in this country more than a 95% reduction. This has been quite a success story.