If they have adenomatous hyperplasia this is a little more severe and I will follow them a little closer. I will re-biopsy them in about three months to make sure we are getting improvement. If they have atypical adenomatous hyperplasia - and nowadays you’ll see this described as cystic hyperplasia with atypia, I think is what many of the pathologists are using now. This can be a very dangerous proposition. Thirty percent will become cancer within 10 years, 20% will already have a focal adenocarcinoma present. I think if you are going to treat with progestins you need to do something to evaluate the endometrium very thoroughly, such as a hysteroscopy or something like that before you fall back on this. You can reverse it with progestins but you have to follow it up very carefully.
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Hormone replacement therapy: a lot of people advocate biopsying them and then adjusting the estrogen/progestin balance as necessary if you are having trouble with spotting or breakthrough bleeding with these patients. For menopausal patients, if they are close to their menopause - within two years of cessation of their menses - I kind of tend to put them on a cyclic program for about a year to a year and a half because they may have some endometrium that is still there and it just hasn’t regressed all the way and if you start on both estrogen/progestin therapy then I feel that you may run into more spotting and breakthrough bleeding and end up doing more of these biopsies. Patients oftentimes don’t like biopsies, especially if I do them because I use about a 4 mm cannula on the end of a 60 cc syringe. I get rid of a lot of polyps and things that way too, but it is uncomfortable. I always fell though that if I don’t get anything when I biopsy them then there’s nothing there worth getting. A lot of people use pipelles which are very comfortable, very easy to use, but I don’t think they give you quite as good a specimen.
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Patients that are just becoming menopausal - say she quit menstruating three to six months about - and you want to know, should you biopsy her before you start her on estrogens. Does she have any endometrial growth? It’s perfectly acceptable for you to give her 10 days of Provera and see if she has a withdrawal bleed. If she doesn’t, then go ahead and start her on estrogen and progestin replacement therapy because she’s got no endometrium of any significance to cause a problem. If they are on hormone replacement therapy and you are having difficulty balancing estrogen/progestin levels, biopsy and see what’s happening. Sometimes you’ll get a proliferative report back which means that you don’t have enough progestin and you just need to bump the progestin up a little bit. If you get an atrophic pattern back then that means that you may need to bump the estrogen up a little bit to prevent them from being too thin and from getting oozing out of the capillaries.
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For patients on Depo-Provera , how long to I let them go without having a menstrual period if they become amenorrheic? Or when they don’t want to take Depo shots any longer, how long will I let them be amenorrheic before I’ll intervene? The thing about Depo-Provera is its effects last for a long time. About 50% of patients will still be anovulatory after their last shot at a six month time frame. Some of them as long as 18 months. You have two choices. The first thing I would is, if the patient wanted to get back to menstruating, I would give her Provera. Do a Provera withdrawal test. If she does not respond to that then she has not developed enough endometrium to start menstruating from. Then you are at the point where you could interfere by giving them estrogen and progestin and then start cycling them on that. My other choice would be, if they are interested in conception, is to give them Clomid to stimulate ovulation, to stimulate the ovaries to working again. I have seen patients go as long as 18 months without menses, without ovulation, after their last Depo-Provera shot. Depo-Provera is a very potent long-lasting drug and if you give it it’s going to be awhile before they get rid of the effects.
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How long will I let a smoking woman take oral contraceptives before I’ll take her off? I’ll let her go to menopause and long as she and I agree on a contract. I will discuss with her her increased risk of cardiovascular disease on the oral contraceptives, I will cut her back to like low estrin or Elise which are 20 mcg pills and I will see them every three to six months if I have any concern about their blood pressure or cardiac status. But I will very carefully follow them along as long as they agree that if they have chest pain, stomach discomfort or heartburn that doesn’t go away - pain in the neck, pain in the back. They will call me and either come to the ER or come to my office for me to see them.
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