Diseases, Disorders information

A report of atypical glandular cells of undetermined significance should indicate, when possible, whether an endometrial or endocervical origin is favored. Atypical endometrial cells should be evaluated by endometrial biopsy. Atypical endocervical cells are further subclassified as favoring either a reactive or a neoplastic process. In a series of 63 patients, 2 women had invasive adenocarcinoma, 5 women had adenocarcinoma in situ, and 17 women had high-grade squamous intraepithelial lesions. Women with atypical glandular cells of undetermined significance should undergo colposcopy with directed biopsy and evaluation of the endocervical canal by endocervical curettage or brush. If the abnormality is not resolved, further diagnostic tests such as conization or hysteroscopy should be considered. Endometrial biopsy should be considered in women older than age 35 with this report. Consultation with a gynecologic oncologist may be helpful if all the results of the diagnostic tests are negative.